Non-coding RNAs: regulators of disease

The Role of Long Non-Coding RNAs in Ovarian Cancer

Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-co...

Long non-coding RNAs – Novel regulators of the Immune Response?

Long non-coding RNAs as key regulators of cancer metastasis

Long non-coding RNAs as key regulators of cancer metastasis Pratirodh Koirala1, De-Hong Zou2, Yin-Yuan Mo1,3 1Department of Biochemistry and Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39201, USA. 2Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China. 3Department of Pharmacology/Toxicology, University of Mississippi Medical Center, Jackson, ...

Non-coding RNAs as regulators of gene expression and epigenetics.

Genome-wide studies have revealed that mammalian genomes are pervasively transcribed. This has led to the identification and isolation of novel classes of non-coding RNAs (ncRNAs) that influence gene expression by a variety of mechanisms. Here we review the characteristics and functions of regulatory ncRNAs in chromatin remodelling and at multiple levels of transcriptional and post-transcriptio...

Non-Coding RNAs as Regulators of Transcription and Genome Organization

“Junk DNA” was used as the provisional label for the portions of a genome for which no discernible function had been identified [1]. In a 1980 review in Nature Leslie Orgel and Francis Crick described junk DNA as having “little specificity and conveying little or no selective advantage to the organism” [2]. For decades, scientist considered the non-protein-coding portions of the genome as dispe...